Journal article
Broad-spectrum non-nucleoside inhibitors for caliciviruses
NE Netzler, D Enosi Tuipulotu, AA Eltahla, JH Lun, S Ferla, A Brancale, N Urakova, M Frese, T Strive, JM Mackenzie, PA White
Antiviral Research | ELSEVIER | Published : 2017
Abstract
Viruses of the Caliciviridae cause significant and sometimes lethal diseases, however despite substantial research efforts, specific antivirals are lacking. Broad-spectrum antivirals could combat multiple viral pathogens, offering a rapid solution when no therapies exist. The RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target as it is essential for viral replication and lacks mammalian homologs. To focus the search for pan-Caliciviridae antivirals, the RdRp was probed with non-nucleoside inhibitors (NNIs) developed against hepatitis C virus (HCV) to reveal both allosteric ligands for structure-activity relationship enhancement, and highly-conserved RdRp pockets for antivir..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
This work was partially funded by a National Health and Medical Research Council project grants (APP1083139 and APP1123135). NN, JL and DE acknowledge support through Australian Postgraduate Awards, and JL acknowledges additional support from a Water Research Australia Postgraduate Scholarship. NU acknowledges support from the Invasive Animals Cooperative Research Centre and a University of Canberra International Postgraduate Research Scholarship. SF and AB acknowledge support from the Life Science Research Network Wales grant no. NRNPGSep14008, an initiative funded through the Welsh Government's Ser Cymru program. The funding bodies had no role in the project design, data collection, analysis, interpretation, writing or decision to submit this article.